Cell Scale
Cell Scale Platform
Cell Scale is a technological platform dedicated to the development, engineering, and functional evaluation of new cellular immunotherapies ; more specifically on approaches based on CAR cells (CAR-T, CAR-NK, CAR-γδ T). Academics and industries have access to this integrated cutting-edge expertise, from vector design to in vivo preclinical validation.
Purposes
Cell Scale supports research and innovative projects in cellular immunotherapy at all stages of preclinical development. The platform has been designed to address the following needs:
- Developping next-generation cellular therapies (CAR-T, CAR-NK, CAR-γδ T)
- Testing and validate innovative antibody formats and chimeric receptors
- Generating functional proof-of-concept data in vitro and in vivo
- Implementing standardized workflows for the production and evaluation of engineered cells
- Accelerating the translation of fundamental discoveries into translational applications
- Supporting both emerging and advanced academic and industrial projects
Embedded within the MIB ecosystem, Cell Scale plays a key role from the identification of new therapeutic targets to their functional validation, in connection with other platforms such as B-Screen.
CELL SCALE
Technology
Cell Scale relies on an integrated approach combining cellular engineering, molecular biology, functional immunology, and preclinical models. The platform provides access to state-of-the-art technologies for:
Ingénierie génétique et cellulaire
- Design and optimization of viral vectors
- Development of CAR constructs and innovative transgenes
- Transduction of immune cells (T lymphocytes, NK cells, and γδ T cells)
- Generation of multispecific CARs
Expansion et caractérisation cellulaire
- Small- and large-scale cell expansion
- Phenotyping and characterization by flow cytometry
- Analysis of transgene expression and cell viability
Évaluation fonctionnelle
- Targeted cytotoxicity assays
- Cytokine quantification
- Cell–target interaction studies
- In vivo preclinical models for therapeutic efficacy validation
This integrated approach helps shorten development timelines, improve data robustness, and secure technological choices from the earliest stages of project design.
Key Capabilities
The Cell Scale platform offers a comprehensive service portfolio covering the entire preclinical development of cellular immunotherapies:
Viral Vector Production
• Lentiviral vector production
• Yield and quality Optimization
• Adaptation to project-specific requirements
Immune Cell Engineering
• Transduction of T, NK, and γδ cells
• Development of customized CAR constructs
• Engineering of functional transgenes
In Vitro Functional Assays
• Targeted cytotoxicity assays
• Cytokines production measurement
• Specificity and efficacy of engineered cells Evaluation
In Vivo Preclinical Validation
• Conduct of in vivo preclinical studies
• Characterization of antitumor efficacy and/or synergistic effects
• Access to a xenobank (>100 tumor-bearing mouse models)
• In vivo optical imaging (bioluminescence and fluorescence)
Scientific and Technological Support
• experimental design
• Standardization of protocols
• Generation of proof-of-concept data
• Interface with academic and industrial partners
Team members
Caroline Imbert
Ingénieure de recherche plateforme Cell-Scale
Daniel Olive
MIB MEDICAL SCIENTIFIC AND TECHNICAL MANAGER
Noella Lopes Pappalardo
Cheffe de projet plateformes technologiques et scientifiques de l’UAR MIBTECH